產品編號 yb-1565R
英文名稱 Anti-APCDD1抗體
中文名稱 腺瘤肉調節蛋白抗體
別    名 adenomatosio polyposis coli down-regulated 1; Adenomatosis polyposis coli down regulated 1; Adenomatosis polyposis coli down regulated 1 protein; APCDD 1; B7323; DRAPC1; FP7019; Protein APCDD1; APCD1_HUMAN.
Anti-APCDD1抗體
說 明 書 0.1ml  0.2ml  
研究領域 腫瘤  免疫學  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Rabbit, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human APCDD1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
APCDD1 is a novel protein that has been shown to be a target of Wnt/beta catenin signaling pathway in cancer cell lines. APCDD1 is overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1 mutated Wilms tumors. [FUNCTION] Probably plays a role in colorectal tumorigenesis. May be a developmental target gene of the Wnt/Beta-catenin pathway.
[SUBCELLULAR LOCATION] Membrane; Single-pass type I membrane protein (Potential). 
[TISSUE SPECIFICITY] Abundantly expressed in heart, pancreas, prostate and ovary. Moderay expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. 
[INDUCTION] Transcriptionally regulated by the CTNNB1/TF7L2complex.

Function:
Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.

Subunit:
Homodimer. Interacts with LRP5 and WNT3A.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Abundantly expressed in heart, pancreas, prostate and ovary. Moderay expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).

Post-translational modifications:
N-Glycosylated.

DISEASE:
Hypotrichosis 1 (HYPT1) [MIM:605389]: A rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the APCDD1 family.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.