產(chǎn)品編號(hào) yb-0055R
英文名稱 Anti-Artemin抗體
中文名稱 Artemin抗體
別    名 Artemin; ARTN; Enovin; EVN; NBN; Neublastin
Anti-Artemin抗體  
說 明 書 0.2ml  
研究領(lǐng)域 發(fā)育生物學(xué)  神經(jīng)生物學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 12kDa
細(xì)胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from the middle of human Artemin
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Artemin is a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFR alpha3-RET receptor complex. The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenrative disease. Artemin has been shown in culture to support the survival of a number of periferal neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Four alternatively spliced transcripts have been described, two of which encode the same protein. 

Function:
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity).

Subunit:
Homodimer; disulfide-linked. Binds to RET.

Subcellular Location:
Secreted.

Tissue Specificity:
Cochlea. Expressed at higher level in sesorineural epithelium than in the modiolus region or substantia nigra.

Similarity:
Belongs to the TGF-beta family. GDNF subfamily.

是GDNF 家族的一個(gè)新成員，已被證實(shí)它是從前的孤兒受體GFRalpha3-RET的配體。
Artemin是感覺和交感神經(jīng)元培養(yǎng)的一個(gè)存活因子，它的表達(dá)形式也影響體內(nèi)的這些神經(jīng)元。Artemin 還能激活GFRalpha1-RET 復(fù)合物并支持培養(yǎng)中腦多巴胺神經(jīng)元存活。