英文名稱 Anti-F-Aromatase抗體
中文名稱 芳香化酶抗體
別    名 Cytochrome p450 19A1; Estrogen synthetase; ARO 1; ARO; ARO1; CPV; CYPXIX; Cytochrome P450 19A1; Cytochrome P450 family 19 subfamily A polypeptide 1; MGC104309; P 450AROM; P450AROM; CP19A_HUMAN; Cytochrome P-450AROM.
Anti-F-Aromatase抗體  
說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  神經生物學  信號轉導  激酶和磷酸酶  合成與降解  
抗體來源 Mouse
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Aromatase N-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, oestrogen biosynthesis, fertility and carcinogenesis. It is highly conserved amongst mammals, and is highly expressed in placental tissue. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function.

Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Subcellular Location:
Membrane; Peripheral membrane protein.

Tissue Specificity:
Brain, placenta and gonads.

DISEASE:
Aromatase excess syndrome (AEXS) [MIM:139300]: An autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females. Note=The disease is caused by mutations affecting the gene represented in this entry. 
Aromatase deficiency (AROD) [MIM:613546]: A rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the cytochrome P450 family.


細胞色素氧化酶p450; 是一種微粒體酶系統，催化睪酮經三步連續強化轉變成17-β-雌二醇,在反應中睪酮作為激素原。
細胞色素P450主要分布在內質網和線粒體內膜上，作為一種末端加氧酶，參與了生物體內的甾醇類激素合成等過程。
近年來，對細胞色素P450的結構、功能特別是對其在藥物代謝中的作用的研究有了較大的進展。
研究表明細胞色素P450還是藥物代謝過程中的關鍵酶，而且對細胞因子和體溫調節都有重要影響。
芳香化酶-細胞色素P450作為和藥物代謝及細胞因子相關的重要酶類，在藥物代謝和免疫中起著相當重要的作用，對于它的研究將有助于新藥的開發，并能幫助人們更加清楚的認識藥物的代謝途徑，在未來的新藥中減少副作用，增加藥物療效。隨著對細胞色素P450研究的深入，將有更多相關的藥物代謝途徑被發現，人們開發新藥的視野將更加開闊，新藥開發的速度也將加快，質量進一步提高。
鑒于P450的研究無論在理論上探索生物的生理代謝、選擇進化和生物與環境的關系方面,或在環境保護、農業生態、生物防治、作物基因工程和醫藥衛生等應用方面,都有廣泛的實踐意義,因此,應該受到更大的關注和重視。