產(chǎn)品編號 yb-1164R
英文名稱 Anti-ADFP抗體
中文名稱 脂肪組織分化相關蛋白抗體
別    名 ADFP; Adipophilin; Adipose differentiation related protein; Adipose differentiation-related protein; Perilipin-2; PLIN2; PLIN2_HUMAN; adipophilin; Adipose differentiation related protein; ADRP; MGC10598
Anti-ADFP抗體
說 明 書 0.1ml  0.2ml  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉(zhuǎn)導  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADFP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

Function:
May be involved in development and maintenance of adipose tissue.

Subcellular Location:
Membrane; Peripheral membrane protein.

Tissue Specificity:
Milk lipid globules.

Post-translational modifications:
Acylated; primarily with C14, C16 and C18 fatty acids.

Similarity:
Belongs to the perilipin family.

是一種脂滴周圍主要的相關蛋白，它大量分布在脂質(zhì)蓄積正?；虿徽５募毎校侵|(zhì)蓄積的一個特異性標記物。它在脂肪細胞分化早期就有很高的表達，但當脂肪細胞成熟后，它的表達就明顯減少，故稱；脂肪分化相關蛋白。
ADFP在很多組織器官中都發(fā)揮重要作用，它不僅參與脂肪細胞的脂質(zhì)代謝、脂滴的形成及肝內(nèi)三酰甘油（TO）的合成與代謝，還能促進巨噬細胞、平滑肌細胞的泡沫化，長鏈脂肪酸的攝取，乳汁的分泌等。
ADFP的表達異常與動脈粥樣硬化、胰島素抵抗和腫瘤等病理過程密切相關。