產品編號 yb-3921R
英文名稱 Anti-ADCY4抗體
中文名稱 腺苷酸環化酶4抗體
別    名 AC4; Adenylate cyclase 4; adenylate cyclase type 4; Adenylate cyclase type IV; Adenylyl cyclase; ATP pyrophosphate lyase 4; ATP pyrophosphate lyase; ADCY4_HUMAN.
Anti-ADCY4抗體  
說 明 書 0.1ml  0.2ml  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  生長因子和激素  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADCY4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
The ADCY4 gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants.

Function:
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity). 

Subcellular Location:
Membrane; Multi-pass membrane protein. 

Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 
Contains 2 guanylate cyclase domains. 

Database links:
UniProtKB/Swiss-Prot: Q8NFM4.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.