產(chǎn)品編號 YB-2405R
英文名稱 Anti-AAKR1B1抗體
中文名稱 醛糖還原酶抗體
別    名 MGC134297; ADR; aldehyde reductase 1; Aldehyde reductase; Aldose reductase; aldr 1; ALDR1; low Km aldose reductase.
Anti-AAKR1B1抗體  
說 明 書 0.2ml  
研究領(lǐng)域 心血管  免疫學  激酶和磷酸酶  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AKR1B1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Subunit:
Monomer.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.

Similarity:
Belongs to the aldo/keto reductase family.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

醛糖還原酶是多元醇通路的關(guān)鍵限速酶,當血糖在正常生理水平時，它并不激活，它對葡萄糖的親和力較低。在高血糖狀況下（如糖尿病），磷酸己糖激酶飽和， 醛糖還原酶激活，促使體內(nèi)的葡萄糖轉(zhuǎn)化為*。然而，*脫氫酶（sorbitol dehydrogenase，SDH）的活力并未相應(yīng)地成比例增加，*轉(zhuǎn)化為果糖的效率沒有提高,*本身由于極性強不易通過細胞膜，在細胞內(nèi)會形成蓄積，使細胞膜的通透性發(fā)生改變，并使細胞中Na+-K+-ATP酶活性下降，造成肌醇喪失，導致細胞代謝與功能的損害。
因眼睛和神經(jīng)細胞等組織內(nèi)醛糖還原酶的含量較高，糖尿病病人體內(nèi)高血糖的環(huán)境使這一通路很容易被打開，造成對相關(guān)組織的病理損害，如糖尿病、白內(nèi)障、神經(jīng)病變、腎臟病變、視網(wǎng)膜病變、動脈粥樣硬化等糖尿病并發(fā)癥DCC的發(fā)生。