產品編號 yb-0443R
英文名稱 Anti-ACTH （1-39）抗體
中文名稱 促腎上腺皮質激素(1-39)抗體
別    名 Adrenocorticotropic hormone; Adrenocorticotropin; Adrenocorticotropin Hormone; Alpha Melanocyte Stimulating Hormone; Beta Lipotropin; Beta Melanocyte Stimulating Hormone; CLIP; Corticotropin; Corticotropin Like Intermediary Peptide; Corticotropin lipotropin precursor; Lipotropin Beta; Lipotropin Gamma; LPH; Melanotropin Alpha; Met Enkephalin; MSH; NPP; POC; POMC; Pro opiomelanocortin; Proopiomelanocortin; COLI_HUMAN.
Anti-ACTH （1-39）抗體
說 明 書 0.1ml  0.2ml  
研究領域 腫瘤  神經生物學  信號轉導  生長因子和激素  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Cow, Goat, 
產品應用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 4.5kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ACTH(1-39)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

Function:
ACTH stimulates the adrenal glands to release cortisol. 
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. 
Beta-endorphin and Met-enkephalin are endogenous opiates. 

Subcellular Location:
Secreted.

Tissue Specificity:
ACTH and MSH are produced by the pituitary gland.

Post-translational modifications:
Specific enzymatic cleavages at paired basic residues yield the different active peptides. 
O-glycosylated; reducing sugar is probably N-acetylgalactosamine. 

DISEASE:
Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. 
Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.

Similarity:
Belongs to the POMC family.


促腎上腺皮質激素(Adrenorticotrophin hormons, ACTH)是垂體前葉細胞分泌的一種多肽激素，是腎上腺皮質活性的主要調節者。
此抗體可與人的ACTH反應,與多種其它哺乳動物的ACTH有交叉反應，可用于垂體腺瘤的功能性分類，有助于區分原發性和轉移型垂體腫瘤，嗜絡細胞瘤等部分神經內分泌腫瘤也可出現陽性反應.